IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Abstract
IL-17A is expressed in the tumor microenvironment where it appears to contribute to tumor development, but its precise role in tumor immunity remains controversial. Here we report mouse genetic evidence that IL-17A is critical for tumor growth. IL-17A-deficient mice exhibited reduced tumor growth, whereas systemic administration of recombinant mouse IL-17A promoted the growth of hepatocellular carcinoma (HCC). The tumor promoting effect of...
Paper Details
Title
IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Published Date
Apr 1, 2014
Journal
Volume
74
Issue
7
Pages
1969 - 1982
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