Extrapolating from animal studies to the efficacy in humans of a pretreatment combination against organophosphate poisoning
Abstract
The extrapolation from animal data to therapeutic effects in humans, a basic pharmacological issue, is especially critical in studies aimed to estimate the protective efficacy of drugs against nerve agent poisoning. Such efficacy can only be predicted by extrapolation of data from animal studies to humans. In pretreatment therapy against nerve agents, careful dose determination is even more crucial than in antidotal therapy, since excessive...
Paper Details
Title
Extrapolating from animal studies to the efficacy in humans of a pretreatment combination against organophosphate poisoning
Published Date
Sep 29, 2006
Journal
Volume
81
Issue
5
Pages
353 - 359
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