The WXXW motif in the TSR1 of ADAMTS13 is important for its secretion and proteolytic activity

Introduction ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) is a metalloprotease enzyme that regulates the size and activity of the von Willebrand factor (VWF). ADAMTS13, like many other ADAMTSs, has a WXXW motif in its thrombospondin type 1 repeat domain (TSR1). However, the function of the WXXW motif in ADAMTSs is unclear. Materials and Methods The constructs of wild-type (WT) and WXXW mutant (W387A)...