Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury

Published on Oct 18, 2015in Oxidative Medicine and Cellular Longevity5.076
· DOI :10.1155/2015/606981
Xinhua Zhou2
Estimated H-index: 2
(JNU: Jinan University),
Longjun Zhu3
Estimated H-index: 3
(JNU: Jinan University)
+ 7 AuthorsYuqiang Wang25
Estimated H-index: 25
(JNU: Jinan University)
Sources
Abstract
Edaravone (EDA) is clinically used for treatment of acute ischemic stroke in Japan and China due to its potent free radical-scavenging effect. However, it has yet to be determined whether EDA can attenuate iodoacetic acid- (IAA-) induced neuronal death in vitro. In the present study, we investigated the effect of EDA on damage of IAA-induced primary cerebellar granule neurons (CGNs) and its possible underlying mechanisms. We found that EDA attenuated IAA-induced cell injury in CGNs. Moreover, EDA significantly reduced intracellular reactive oxidative stress production, loss of mitochondrial membrane potential, and caspase 3 activity induced by IAA. Taken together, EDA protected CGNs against IAA-induced neuronal damage, which may be attributed to its antiapoptotic and antioxidative activities.
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