Tissue-Specific Differences in the Development of Insulin Resistance in a Mouse Model for Type 1 Diabetes
Abstract
Although insulin resistance is known to underlie type 2 diabetes, its role in the development of type 1 diabetes has been gaining increasing interest. In a model of type 1 diabetes, the nonobese diabetic (NOD) mouse, we found that insulin resistance driven by lipid- and glucose-independent mechanisms is already present in the liver of prediabetic mice. Hepatic insulin resistance is associated with a transient rise in mitochondrial respiration...
Paper Details
Title
Tissue-Specific Differences in the Development of Insulin Resistance in a Mouse Model for Type 1 Diabetes
Published Date
Oct 13, 2014
Journal
Volume
63
Issue
11
Pages
3856 - 3867
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