Effect of acute gouty arthritis on sleep patterns: A preclinical study

It has been demonstrated that the interrelation between pain and sleep produces changes in sleep patterns and pain perception. Although some evidences suggest that sleep and pain may interact in a complex way, polysomnographic studies in animals with acute nociception are limited in number.This study was carried out in order to evaluate the effect of intra-articular knee injection of uric acid on sleep-wake patterns.Surgical electrode...