Relapsing course of Immunoglobulin G4-related pachymeningitis

Immunoglobulin G4–related disease (IgG4-RD) is a newly recognized immune-mediated condition that involves multiple organ systems and is frequently characterized by tumefactive lesions. Histopathology demonstrates lymphoplasmacytic infiltrates, storiform fibrosis, and abundant IgG4-positive plasma cells within affected tissues.1 Neurologic manifestations include spinal2,3 and intracranial pachymeningitis.4 One retrospective series suggests that...