Comprehensive Evaluation of Ocular Toxicity of Topical Levofloxacin in Rabbit and Primate Models

Levofloxacin, the L‐isomer of ofloxacin and a potent quinolone with a broad spectrum of antibacterial activity, was evaluated in a series of toxicology studies including acute and chronic dosing in rabbits and primates with intact and injured eyes. No evidence of ocular toxicity was observed in rabbits with intact eyes that were topically instilled with levofloxacin ophthalmic solutions under various treatment regimens, including multiple dosing...