Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.

Volume: 35, Issue: 2, Pages: 171 - 175
Published: Aug 31, 2003
Abstract
The pathophysiology of bipolar disorder is still unclear, although family, twin and linkage studies implicate genetic factors. Here we identified XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, as contributing to the genetic risk factor for bipolar disorder. Using DNA microarray analysis of lymphoblastoid cells derived from two pairs of twins discordant with respect to the illness, we found downregulated expression of...
Paper Details
Title
Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.
Published Date
Aug 31, 2003
Volume
35
Issue
2
Pages
171 - 175
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