Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements
Volume: 299, Issue: 2, Pages: 204 - 211
Published: Feb 1, 2009
Abstract
Selective estrogen receptor modulators (SERMs), such as tamoxifen and raloxifene can act as estrogen receptor (ER) antagonists or agonists depending on the cell type. The antagonistic action of tamoxifen has been invaluable for treating breast cancer, whereas the agonist activity of SERMs also has important clinical applications as demonstrated by the use of raloxifene for osteoporosis. Whereas the mechanism whereby SERMs function as antagonists...
Paper Details
Title
Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements
Published Date
Feb 1, 2009
Volume
299
Issue
2
Pages
204 - 211
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