Bioanalytical assay strategies for the development of antibody–drug conjugate biotherapeutics
Abstract
Antibody-drug conjugates (ADCs) are monoclonal antibodies with covalently bound cytotoxic drugs. They are designed to target tumor antigens selectively and offer the hope of cancer treatment without the debilitating side-effects of conventional therapies. The concept of ADCs is not new; however, development of these therapeutics is challenging and only recently are promising clinical data emerging. These challenges include ADC bioanalysis, such...
Paper Details
Title
Bioanalytical assay strategies for the development of antibody–drug conjugate biotherapeutics
Published Date
Jan 1, 2013
Journal
Volume
5
Issue
2
Pages
201 - 226
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