Synthesis and antibacterial activity of betulin esters

Betulin isonicotinate, 6-chloronicotinate, 2-chlorocinnamate, and benzoates were synthesized by the reaction of betulin and the acid chlorides. It was shown that the 3,4-difluorobenzoate exhibited antibacterial activity against Ochrobactrum anthropi, Stenotrophomonas maltophilia, and S. nitritireducens whereas the 3,5-dinitrobenzoate was active against the last two...