Efficacy and safety of etanercept in chronic immune-mediated disease

Introduction: TNF-α inhibitors have demonstrated efficacy in large, randomized controlled clinical trials either as monotherapy or in combination with other anti-inflammatory or disease-modifying antirheumatic drugs in the treatment of chronic inflammatory immune-mediated diseases. Etanercept is a fusion protein that acts as a ‘decoy receptor’ for TNF-α. Areas covered: This paper evaluates the efficacy and safety of etanercept in patients with...