Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies
Abstract
Lysosomal dysfunction is thought to be a prominent feature in the pathogenetic events leading to Parkinson’s disease (PD). This view is supported by the evidence that mutations in GBA gene, coding the lysosomal hydrolase β-glucocerebrosidase (GCase), are a common genetic risk factor for PD. Recently, GCase activity has been shown to be decreased in substantia nigra and in cerebrospinal fluid of patients diagnosed with PD or dementia with Lewy...
Paper Details
Title
Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies
Published Date
Mar 27, 2015
Journal
Volume
10
Issue
1
Pages
15 - 15
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