Cyclic dinucleotides modulate human T-cell response through monocyte cell death
Abstract
Cyclic dinucleotides, a class of microbial messengers, have been recently identified in bacteria, but their activity in humans remains largely unknown. Here, we have studied the function of cyclic dinucleotides in humans. We found that c-di-AMP and cGAMP, two adenosine-based cyclic dinucleotides, activated T lymphocytes in an unusual manner through monocyte cell death. c-di-AMP and cGAMP induced the selective apoptosis of human monocytes, and T...
Paper Details
Title
Cyclic dinucleotides modulate human T-cell response through monocyte cell death
Published Date
Oct 15, 2015
Volume
45
Issue
12
Pages
3313 - 3323
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