Comparative Ocular Bioavailability and Efficacy of Topical Levofloxacin and Ofloxacin in Rabbits

Levofloxacin and ofloxacin are fluoroquinolone antibacterial agents with activity against a broad spectrum of Gram‐positive and Gram‐negative ocular pathogens. Levofloxacin is the pure S‐(−) isomer of ofloxacin, and is approximately twice as active as the R‐(+) isomer. Studies were conducted to measure the pharmacokinetics of levofloxacin and ofloxacin in the cornea and aqueous humor of the intact rabbit eye and also to determine the therapeutic...