Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts
Abstract
In these studies, the role of ceramide-1-phosphate (C1P) in the wound-healing process was investigated. Specifically, fibroblasts isolated from mice with the known anabolic enzyme for C1P, ceramide kinase (CERK), ablated (CERK(-/-) mice) and their wild-type littermates (CERK(+/+)) were subjected to in vitro wound-healing assays. Simulation of mechanical trauma of a wound by scratching a monolayer of fibroblasts from CERK(+/+) mice demonstrated...
Paper Details
Title
Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts
Published Date
Jul 1, 2014
Journal
Volume
55
Issue
7
Pages
1298 - 1309
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Notes
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