p53-dependent apoptosis contributes to di-(2-ethylhexyl) phthalate-induced hepatotoxicity
Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is used extensively in many personal care and consumer products, resulting in widespread non-occupational human exposure through multiple routes and media. DEHP has various deleterious effects including hepatotoxicity. p53 protein is a central sensor in cell apoptosis. In order to clarify the roles of p53 in DEHP-induced hepatotoxicity, Sprague–Dawley (SD) rats were dosed daily with DEHP by gavage for 30 days;...
Paper Details
Title
p53-dependent apoptosis contributes to di-(2-ethylhexyl) phthalate-induced hepatotoxicity
Published Date
Jan 1, 2016
Journal
Volume
208
Pages
416 - 425
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