Polycaprolactone/hydroxyapatite composite scaffolds: Preparation, characterization, and in vitro and in vivo biological responses of human primary bone cells

Polycaprolactone (PCL) is a synthetic biodegradable polymer that has been approved for use as bone graft substitutes. In this study, PCL scaffolds incorporating hydroxyapatite (HAp) particles were fabricated by combined solvent casting and particulate leaching techniques. The average pore dimension was in the range of about 480-500 microm. The porosity, water absorption, and compressive modulus of the scaffold were evaluated. The responses of...