Improving the oral bioavailability of albendazole in rabbits by the solid dispersion technique

Volume: 51, Issue: 2, Pages: 159 - 164
Published: Feb 18, 2010
Abstract
We have investigated the oral bioavailability of granules of albendazole, a drug used for treating echinococcosis in man, prepared by the solid dispersion technique. Rapid dissolution and supersaturation were observed when hydroxypropylmethylcellulose and hydroxypropylmethylcellulose phthalate were used as carriers in the solid dispersion. They inhibited the crystallization of albendazole from the supersaturated solution and maintained an...
Paper Details
Title
Improving the oral bioavailability of albendazole in rabbits by the solid dispersion technique
Published Date
Feb 18, 2010
Volume
51
Issue
2
Pages
159 - 164
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