IFN-γ Production during Initial Infection Determines the Outcome of Reinfection with Respiratory Syncytial Virus

Volume: 177, Issue: 2, Pages: 208 - 218
Published: Jan 15, 2008
Abstract
Rationale: Severe respiratory syncytial virus (RSV) bronchiolitis has been associated with deficient IFN-γ production in humans, but the role of this cytokine in determining the outcome of reinfection is unknown. Objectives: To define the role of IFN-γ in the development of RSV-mediated airway hyperresponsiveness (AHR) and lung histopathology in mice. Methods: Wild-type (WT) and IFN-γ knockout mice were infected with RSV in the newborn or...
Paper Details
Title
IFN-γ Production during Initial Infection Determines the Outcome of Reinfection with Respiratory Syncytial Virus
Published Date
Jan 15, 2008
Volume
177
Issue
2
Pages
208 - 218
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