The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins A Novel Pathway for Inflammatory Cell Recruitment

Volume: 198, Issue: 10, Pages: 1507 - 1515
Published: Nov 17, 2003
Abstract
The pattern recognition receptor, RAGE (receptor for advanced glycation endproducts), propagates cellular dysfunction in several inflammatory disorders and diabetes. Here we show that RAGE functions as an endothelial adhesion receptor promoting leukocyte recruitment. In an animal model of thioglycollate-induced acute peritonitis, leukocyte recruitment was significantly impaired in RAGE-deficient mice as opposed to wild-type mice. In diabetic...
Paper Details
Title
The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins A Novel Pathway for Inflammatory Cell Recruitment
Published Date
Nov 17, 2003
Volume
198
Issue
10
Pages
1507 - 1515
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