Characterization of the Sulfur Mustard Vapor Induced Cutaneous Lesions on Hairless Guinea Pigs

The identification of antivesicant compounds has been hindered by the lack of a suitable in vivo model. Our laboratory has been evaluating the hairless guinea pig as a useful animal model to mimic the human cutaneous response to sulfur mustard (HD) exposure. The characterization of two cutaneous responses to HD, quantification of erythema using a reflectance color meter, and pathology by light microscopy, is described in this manuscript....