Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.

Volume: 105, Issue: 16, Pages: 6115 - 6120
Published: Apr 22, 2008
Abstract
In mice, recent thymic emigrants (RTEs) make up a large part of the naive T cell pool and have been suggested to be a distinct short-lived pool. In humans, however, the life span and number of RTEs are unknown. Although 2H2O labeling in young mice showed high thymic-dependent daily naive T cell production, long term up- and down-labeling with 2H2O in human adults revealed a low daily production of naive T cells. Using mathematical modeling, we...
Paper Details
Title
Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.
Published Date
Apr 22, 2008
Volume
105
Issue
16
Pages
6115 - 6120
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