Inhalation of a Dry Powder Tobramycin PulmoSphere Formulation in Healthy Volunteers

Study objectives To evaluate the efficiency and reproducibility of pulmonary delivery of an investigational tobramycin PulmoSphere formulation (PStob) [Inhale Therapeutic Systems; San Carlos, CA] by a passive dry powder inhaler, and to compare serum concentrations and whole-lung deposition with a commercial nebulized tobramycin product (TOBI; Chiron Corporation; Seattle, WA). Design A five-period, open-label, nonrandomized crossover study....