Deletion ofAbcg2Has Differential Effects on Excretion and Pharmacokinetics of Probe Substrates in Rats

This study was designed to characterize breast cancer resistance protein (Bcrp) knockout Abcg2(−/−) rats and assess the effect of ATP-binding cassette subfamily G member 2 (Abcg2) deletion on the excretion and pharmacokinetic properties of probe substrates. Deletion of the target gene in the Abcg2(−/−) rats was confirmed, whereas gene expression was unaffected for most of the other transporters and metabolizing enzymes....