Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue

Volume: 63, Issue: 3, Pages: 912 - 922
Published: Feb 13, 2014
Abstract
Endoplasmic reticulum (ER) stress is increased in obesity and is postulated to be a major contributor to many obesity-related pathologies. Little is known about what causes ER stress in obese people. Here, we show that insulin upregulated the unfolded protein response (UPR), an adaptive reaction to ER stress, in vitro in 3T3-L1 adipocytes and in vivo, in subcutaneous (sc) adipose tissue of nondiabetic subjects, where it increased the UPR dose...
Paper Details
Title
Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue
Published Date
Feb 13, 2014
Journal
Volume
63
Issue
3
Pages
912 - 922
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