Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death.
Abstract
Curcumin is a phenolic yellow curry pigment with anti-inflammatory and antioxidant activities and α-mangostin is a xanthone isolated from mangosteen fruit with antioxidant properties. Iodoacetate (IAA) is an inhibitor of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase that induces a model of metabolic inhibition in neurons where reactive oxygen species (ROS) production is a significant mechanism. Furthermore, it has been shown...
Paper Details
Title
Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death.
Published Date
Jul 4, 2012
Journal
Volume
15
Issue
5
Pages
34 - 41
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Notes
History