A cellular screening assay to test the ability of PKR to induce cell death in mammalian cells
Abstract
Long double-stranded RNA (>30 bp), usually expressed in cells infected with RNA viruses, triggers antiviral responses that induce apoptosis of the infected cells. PKR can be selectively activated in glioblastoma cells by in situ generation of dsRNA following introduction of antisense RNA complementary to an RNA expressed specifically in these cells. Harnessing PKR for the selective killing of cancer cells is potentially a powerful strategy for...
Paper Details
Title
A cellular screening assay to test the ability of PKR to induce cell death in mammalian cells
Published Date
Nov 1, 2005
Journal
Volume
12
Issue
5
Pages
969 - 975
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Notes
History