TAM Receptor Signaling in Immune Homeostasis
Abstract
The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response,...
Paper Details
Title
TAM Receptor Signaling in Immune Homeostasis
Published Date
Mar 21, 2015
Journal
Volume
33
Issue
1
Pages
355 - 391
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History