Aberrations in the epidermal growth factor receptor gene in 958 patients with diverse advanced tumors: implications for therapy

BackgroundEpidermal growth factor receptor (EGFR) mutations are associated with the response to EGFR inhibitors in patients with non-small-cell lung cancer (NSCLC). We sought to investigate EGFR aberrations in patients with diverse advanced cancers.Patients and methodsPatients referred to the phase I clinic were evaluated for the presence of EGFR mutations and response to therapy.ResultsEGFR aberrations were detected in 34 of 958 patients...