Fibroblast growth factors and their receptors in cancer
Abstract
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly regulating cell proliferation, survival, migration and differentiation during development and adult life. Deregulation of FGFR signalling, on the other hand, has been associated with many developmental syndromes, and with human cancer. In cancer, FGFRs have been found to become overactivated by several mechanisms, including gene amplification,...
Paper Details
Title
Fibroblast growth factors and their receptors in cancer
Published Date
Jun 28, 2011
Journal
Volume
437
Issue
2
Pages
199 - 213
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Notes
History