Inhibition of Atherogenesis in BLT1-Deficient Mice Reveals a Role for LTB4 and BLT1 in Smooth Muscle Cell Recruitment

Background— It is known that 5-lipoxygenase and its product, leukotriene B4 (LTB 4 ), are highly expressed in several human pathologies, including atherosclerotic plaque. LTB 4 signals primarily through its high-affinity G protein-coupled receptor BLT1, which is expressed on specific leukocyte subsets. BLT1 receptor expression and function on other atheroma-associated cell types is unknown. Methods and Results— To directly assess the role of the...