The regulation of T-cell recruitment to the human liver during acute liver failure

Background & Aims Acute liver failure ( ALF ) is a rare clinical syndrome with high mortality resulting from hepatocellular necrosis and loss of function. In seronegative hepatitis ( SNH ), a T‐cell‐rich infiltrate leads to immune‐mediated hepatocyte destruction, whereas in paracetamol poisoning, toxic metabolites induce hepatocyte necrosis, followed by a macrophage‐rich, lymphocytic infiltrate that is an important factor in driving repair...