Pterocarpans and flavanones from Sophora flavescens displaying potent neuraminidase inhibition

Volume: 18, Issue: 23, Pages: 6046 - 6049
Published: Dec 1, 2008
Abstract
Pterocarpans (1-3) and flavanones (4-10) were isolated from Sophora flavescens and screened for their ability to inhibit neuraminidase (an enzyme crucial in the proliferation of the influenza virus). The majority of inhibitors were shown to have IC(50) values of 20 microM or below. Interestingly, pterocarpan 1 emerged as the best inhibitor with an IC(50) of 1.4 microM. We were thus able to prove that the pterocarpan skeleton is a new class of...
Paper Details
Title
Pterocarpans and flavanones from Sophora flavescens displaying potent neuraminidase inhibition
Published Date
Dec 1, 2008
Volume
18
Issue
23
Pages
6046 - 6049
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