Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

Gut24.50
Volume: 65, Issue: 8, Pages: 1333 - 1346
Published: Aug 1, 2016
Abstract
Objective null Acute pancreatitis is caused by toxins that induce acinar cell calcium overload, zymogen activation, cytokine release and cell death, yet is without specific drug therapy. Mitochondrial dysfunction has been implicated but the mechanism not established. null Design null We investigated the mechanism of induction and consequences of the mitochondrial permeability transition pore (MPTP) in the pancreas using cell biological methods...
Paper Details
Title
Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP
Published Date
Aug 1, 2016
Journal
Volume
65
Issue
8
Pages
1333 - 1346
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