Genetic essential tremor in γ-aminobutyric acidA receptor α1 subunit knockout mice
Abstract
Essential tremor is the most common movement disorder and has an unknown etiology. Here we report that γ-aminobutyric acidA (GABAA) receptor α1–/– mice exhibit postural and kinetic tremor and motor incoordination that is characteristic of essential tremor disease. We tested mice with essential-like tremor using current drug therapies that alleviate symptoms in essential tremor patients (primidone, propranolol, and gabapentin) and several...
Paper Details
Title
Genetic essential tremor in γ-aminobutyric acidA receptor α1 subunit knockout mice
Published Date
Mar 1, 2005
Volume
115
Issue
3
Pages
774 - 779
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