Differential expression of 11β‐hydroxysteroid dehydrogenase type 1 and 2 in mild and moderate/severe persistent allergic nasal mucosa and regulation of their expression by Th2 cytokines
Abstract
Summary Background Glucocorticoids are used to treat allergic rhinitis, but the mechanisms by which they induce disease remission are unclear. 11β‐hydroxysteroid dehydrogenase (11β‐ HSD ) is a tissue‐specific regulator of glucocorticoid responses, inducing the interconversion of inactive and active glucocorticoids. Objective We analysed the expression and distribution patterns of 11β‐ HSD 1, 11β‐ HSD 2, and steroidogenic enzymes in normal and...
Paper Details
Title
Differential expression of 11β‐hydroxysteroid dehydrogenase type 1 and 2 in mild and moderate/severe persistent allergic nasal mucosa and regulation of their expression by Th2 cytokines
Published Date
Jan 22, 2014
Volume
44
Issue
2
Pages
197 - 211
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