Metabolic Activation and Inflammation Reactions Involved in Carbamazepine-Induced Liver Injury
Abstract
Drug-induced liver injury is a major safety concern in drug development and clinical pharmacotherapy; however, advances in the understanding of the mechanisms of drug-induced liver injury are hampered by the lack of animal models. Carbamazepine (CBZ) is a widely used antiepileptic agent. Although the drug is generally well tolerated, only a small number of patients prescribed CBZ develop severe hepatitis. In the present study, we developed a...
Paper Details
Title
Metabolic Activation and Inflammation Reactions Involved in Carbamazepine-Induced Liver Injury
Published Date
Jul 12, 2012
Journal
Volume
130
Issue
1
Pages
4 - 16
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