Mechanism of auxiliary β‐subunit‐mediated membrane targeting of L‐type (CaV1.2) channels
Abstract
Ca(2+) influx via Ca(V)1/Ca(V)2 channels drives processes ranging from neurotransmission to muscle contraction. Association of a pore-forming α(1) and cytosolic β is necessary for trafficking Ca(V)1/Ca(V)2 channels to the cell surface through poorly understood mechanisms. A prevalent idea suggests β binds the α(1) intracellular I-II loop, masking an endoplasmic reticulum (ER) retention signal as the dominant mechanism for Ca(V)1/Ca(V)2 channel...
Paper Details
Title
Mechanism of auxiliary β‐subunit‐mediated membrane targeting of L‐type (CaV1.2) channels
Published Date
Sep 1, 2011
Journal
Volume
589
Issue
18
Pages
4437 - 4455
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