Evolutionary history of the TBP-domain superfamily

Volume: 41, Issue: 5, Pages: 2832 - 2845
Published: Feb 1, 2013
Abstract
The TATA binding protein (TBP) is an essential transcription initiation factor in Archaea and Eucarya. Bacteria lack TBP, and instead use sigma factors for transcription initiation. TBP has a symmetric structure comprising two repeated TBP domains. Using sequence, structural and phylogenetic analyses, we examine the distribution and evolutionary history of the TBP domain, a member of the helix-grip fold family. Our analyses reveal a broader...
Paper Details
Title
Evolutionary history of the TBP-domain superfamily
Published Date
Feb 1, 2013
Volume
41
Issue
5
Pages
2832 - 2845
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