Molecular Pathways: Targeting NRG1 Fusions in Lung Cancer

Volume: 21, Issue: 9, Pages: 1989 - 1994
Published: May 1, 2015
Abstract
The four members of the ERBB (HER) family of transmembrane receptor tyrosine kinases are frequently activated in cancer by several mechanisms, such as mutation, amplification, or autocrine ligand-receptor stimulation. We recently identified gene fusions involving the ERBB ligand gene, NRG1, which represent a novel mechanism for ERBB pathway deregulation. These fusions lead to expression and presentation of the EGF-like domain of NRG1 on the cell...
Paper Details
Title
Molecular Pathways: Targeting NRG1 Fusions in Lung Cancer
Published Date
May 1, 2015
Volume
21
Issue
9
Pages
1989 - 1994
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