Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Abstract
Noisy gene expression or unequal partition of molecules during cell division are increasingly recognized as key sources of non-genetic cell-to-cell heterogeneity but the consequences for disease progression and drug efficiency are little understood. Through single-cell imaging, Spencer et al. now show that pre-existing cell-to-cell differences in the levels of signalling proteins determine whether the addition of an external death signal will...
Paper Details
Title
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Published Date
May 21, 2009
Journal
Volume
459
Issue
7245
Pages
428 - 432
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