Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

Volume: 12, Issue: 5, Pages: 458 - 465
Published: May 1, 2013
Abstract
Although cell-matrix adhesive interactions are known to regulate stem cell differentiation, the underlying mechanisms, in particular for direct three-dimensional encapsulation within hydrogels, are poorly understood. Here, we demonstrate that in covalently crosslinked hyaluronic acid (HA) hydrogels, the differentiation of human mesenchymal stem cells (hMSCs) is directed by the generation of degradation-mediated cellular traction, independently...
Paper Details
Title
Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels
Published Date
May 1, 2013
Volume
12
Issue
5
Pages
458 - 465
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