Colorectal carcinoma: Importance of colonic environment for anti-cancer response and systemic immunity.

Published on Nov 12, 2009in Journal of Immunotoxicology2.974
· DOI :10.3109/15476910903334343
Luca Vannucci22
Estimated H-index: 22
(CAS: Academy of Sciences of the Czech Republic),
Renata Stepankova21
Estimated H-index: 21
(CAS: Academy of Sciences of the Czech Republic)
+ 7 AuthorsHelena Tlaskalova-Hogenova51
Estimated H-index: 51
(CAS: Academy of Sciences of the Czech Republic)
The intestinal environment is considered to play an important role both in colorectal tumor development and in the evolution and modulation of mucosal immunity. Studies in animals reared in germ-free (GF, without any intestinal microflora) versus conventional (CV, with regular microflora in bowel) conditions can aid in clarifying the influence of bacteria on carcinogenesis and anti-cancer immune responses in situ. The lower incidence of colon cancers and better immunological parameters in GF animals versus CV ones after chemically-induced carcinogenesis raises questions about specific characteristics of the immunological networks in each respective condition. Different levels of tolerance/regulatory mechanisms in the GF versus CV animals may influence the development of immune responses not only at the level of mucosal, but also at the systemic, immunity. We hypothesize that GF animals can better recognize and respond to evolving neoplasias in the bowel as a consequence of their less-tolerogenic immunity ...
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