A recombinant human enzyme for enhanced interstitial transport of therapeutics
Abstract
Subcutaneously injected therapeutics must pass through the interstitial matrix of the skin in order to reach their intended targets. This complex, three-dimensional structure limits the type and quantity of drugs that can be administered by local injection. Here we found that depolymerization of the viscoelastic component of the interstitial matrix in animal models with a highly purified recombinant human hyaluronidase enzyme (rHuPH20) increased...
Paper Details
Title
A recombinant human enzyme for enhanced interstitial transport of therapeutics
Published Date
Aug 1, 2006
Volume
114
Issue
2
Pages
230 - 241
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