Dose–Volume Effects in Rat Thoracolumbar Spinal Cord: The Effects of Nonuniform Dose Distribution

Purpose To investigate dose–volume effects in rat spinal cord irradiated with nonuniform dose distributions and to assess regional differences in radiosensitivity. Methods and Materials A total of 106 rats divided into three groups were irradiated with 192Ir γ-rays at a high dose rate. The groups were irradiated with one, two, or six catheters distributed around the thoracolumbar spinal cord to create different dose distributions. After...