High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome

Published on Jan 25, 2012in Nutrition & Metabolism3.211
· DOI :10.1186/1743-7075-9-4
Ayumu Hirata17
Estimated H-index: 17
(Osaka University),
Ken Kishida35
Estimated H-index: 35
(Osaka University)
+ 4 AuthorsIichiro Shimomura26
Estimated H-index: 26
(Osaka University)
Background: The prevalence of gastroesophageal reflux disease (GERD) has been increasing worldwide. Abdominal obesity or visceral fat accumulation rather than simple obesity is associated with GERD. Previous reports demonstrated the association between GERD and type 2 diabetes mellitus (T2DM). Signification of visceral fat accumulation and adiponectin in T2DM patients with GERD remains unclear. The present study investigated the relationships between GERD symptoms, visceral fat accumulation and adiponectin in subjects with T2DM. Findings: The study (ADMIT study) subjects were 66 Japanese T2DM outpatients, who answered the questionnaire regarding GERD symptoms in Frequency Scale for the Symptoms of GERD (FSSG), and were measured visceral fat area by bioelectrical impedance analysis. Patients with FSSG scores of more than 8 were considered as positive. The prevalence of FSSG score ≥ 8 and average FSSG score in T2DM subjects with the metabolic syndrome (Mets) were significantly higher compared to those without Mets. The prevalence of FSSG score ≥ 8 and average FSSG score in T2DM subjects with low levels of serum adiponectin were significantly higher compared to those with high levels of serum adiponectin. Moreover, the combination of Mets and hypoadiponectinemia had a multiplicative effect on GERD symptom score (p = 0.047). Conclusions: Our study showed that the coexistence of MetS and low levels of serum adiponectin was associated with the higher prevalence of FSSG score ≥ 8 and the higher scores of GERD symptom in subjects with T2DM. Trial Registration UMIN 000002271.
📖 Papers frequently viewed together
57 Citations
29 Citations
79 Citations
#1Ayumu Hirata (Osaka University)H-Index: 17
#2Ken Kishida (Osaka University)H-Index: 35
Last. Iichiro Shimomura (Osaka University)H-Index: 26
view all 6 authors...
Abstract Objective Patients with type 2 diabetes mellitus (T2DM) are at risk of polyvascular comorbidities and poor prognosis. Non-invasive techniques for early prediction of coronary artery disease (CAD) are desirable to prevent cardiovascular events in these patients. The aim of the present study was to investigate the association between CAD and systemic arteriosclerosis by qualitative vascular ultrasonography. Methods The study subjects were 102 consecutive outpatients with T2DM [males/femal...
15 CitationsSource
#1Motohiko Kato (Osaka University)H-Index: 20
#2Kenji Watabe (Osaka University)H-Index: 19
Last. Yuji MatsuzawaH-Index: 130
view all 18 authors...
Background Obesity is a risk factor for gastro-esophageal reflux disease (GERD). It is generally considered that intra-abdominal pressure in obese subjects is involved in the pathogenesis of GERD through acid exposure to the esophagus. Recently, visceral fat has been recognized as an endocrine organ that secretes various adipocytokines including adiponectin. The aim of this study was to elucidate the relation between adiponectin and erosive esophagitis.
28 CitationsSource
#1Susumu Kashine (Osaka University)H-Index: 10
#2Ken Kishida (Osaka University)H-Index: 35
Last. Iichiro Shimomura (Osaka University)H-Index: 26
view all 7 authors...
Objective Sleep-disordered breathing (SDB) is a potential risk factor for cardiac sudden death. Recent studies have reported that patients with type 2 diabetes mellitus (T2DM) frequently suffer from SDB. Although the roles of hyperglycemia, disturbances of the autonomic nervous system and obesity have been postulated, the factors related to SDB in T2DM, especially those related to improvement of SDB remain unknown. We investigated the significance of waist circumference (WC), representing excess...
9 CitationsSource
#1Sabine Roman (NU: Northwestern University)H-Index: 59
#2John E. Pandolfino (NU: Northwestern University)H-Index: 79
The prevalence of Gastro-Oesophageal Reflux Disease (GORD) has been increasing worldwide. This increase is likely associated with the increased prevalence of obesity, the ageing of the population and the decreased prevalence of Helicobacter pylori (Hp) infection. These different environmental factors interact with GORD pathogenesis in a potentially negative way. Oesophago-gastric junction (OGJ) competence, oesophageal clearance mechanisms and reflux causticity are involved in GORD pathophysiolog...
15 CitationsSource
#1Yukiyoshi Okauchi (Osaka University)H-Index: 14
#2Ken Kishida (Osaka University)H-Index: 35
Last. Iichiro Shimomura (Osaka University)H-Index: 26
view all 12 authors...
Aim: The accumulation of Visceral fat is known to precede metabolic disorders and atherosclerosis. This study aimed to determine the relationships between body mass index (BMI), waist circumference (WC), estimated visceral fat area (eVFA) measured by bioelectrical impedance analysis (BIA), and obesity-related cardiovascular risk factors. Methods: The study population was 2,870 middle-aged Japanese employees (males/females=2,322/ 548), who had undergone a health check-up. Results: In the receiver...
26 CitationsSource
#1Hideaki Nakatsuji (Osaka University)H-Index: 16
#2Ken Kishida (Osaka University)H-Index: 35
Last. Iichiro Shimomura (Osaka University)H-Index: 88
view all 4 authors...
19 CitationsSource
#1Shahin Ayazi (SC: University of Southern California)H-Index: 22
#2Jeffrey A. Hagen (SC: University of Southern California)H-Index: 69
Last. Peter F. Crookes (SC: University of Southern California)H-Index: 54
view all 12 authors...
1 CitationsSource
#1Shahin Ayazi (SC: University of Southern California)H-Index: 22
#2Jeffrey A. Hagen (SC: University of Southern California)H-Index: 69
Last. Peter F. Crookes (SC: University of Southern California)H-Index: 54
view all 12 authors...
Introduction Obesity and gastroesophageal reflux disease (GERD) are increasingly important health problems. Previous studies of the relationship between obesity and GERD focus on indirect manifestations of GERD. Little is known about the association between obesity and objectively measured esophageal acid exposure. The aim of this study is to quantify the relationship between body mass index (BMI) and 24-h esophageal pH measurements and the status of the lower esophageal sphincter (LES) in patie...
134 CitationsSource
#1Akiko Danjo (Saga: Saga Group)H-Index: 4
#2Kanako Yamaguchi (Saga: Saga Group)H-Index: 1
Last. Motoyasu Kusano (Gunma University)H-Index: 29
view all 19 authors...
Background and Aim: We compared endoscopic findings of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), a written questionnaire developed in Japan, to that for the questionnaire for the diagnosis of reflux esophagitis (QUEST) for the diagnosis of reflux esophagitis. Methods: We registered 475 patients with untreated symptoms of upper abdominal pain (male/female: 252/223, average age 52.4 ± 17.8 years). Subjects were assessed first with the FSSG and QUEST questionna...
57 CitationsSource
#1A. Horikawa (Meiji Pharmaceutical University)H-Index: 1
#2R. Ishii-Nozawa (Meiji Pharmaceutical University)H-Index: 1
Last. K. Takeuchi (Meiji Pharmaceutical University)H-Index: 1
view all 10 authors...
Aims To examine the incidence of gastro-oesophageal reflux disease (GORD) and its associated factors in patients with Type 2 diabetes mellitus (Type 2 DM). Methods In 859 Type 2 DM outpatients, we conducted a QUEST inquiry and considered those showing a QUEST score of 4 or higher as having GORD. We surveyed clinical variables {physical findings, gender, age, duration of disease, glycated haemoglobin (HbA1c), type of oral glucose-lowering agent, presence or absence of insulin therapy, complicatio...
22 CitationsSource
Cited By18
#1Aleksey Oparin (Kharkiv Medical Academy of Postgraduate Education)H-Index: 1
#2Anton Kudriavtsev (Kharkiv Medical Academy of Postgraduate Education)H-Index: 1
Last. Anatoliy Oparin (Kharkiv Medical Academy of Postgraduate Education)H-Index: 2
view all 3 authors...
Diabetes mellitus is one of the most serious problems of the clinical medicine. This is determined by the fact that it is followed by multisystemic affects, as well as complications on the side of other organs and systems, among which a special place is occupied by gastroesophageal reflux disease. As for the combination and mutual influence of diabetes mellitus and gastroesophageal reflux disease, this issue has not been studied yet, the data of modern literature are not complete and quite contr...
1 CitationsSource
#1Hiroyuki Honda (Okayama University)H-Index: 1
#2Yoshihisa Hanayama (Okayama University)H-Index: 6
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 10 authors...
A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients' gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (>/= 36) sh...
#1Suut Gokturk (Istanbul University)H-Index: 8
#2Filiz Akyuz (Istanbul University)H-Index: 17
Last. Fatih Besisik (Istanbul University)H-Index: 21
view all 16 authors...
Introduction Gastroesophageal reflux disease (GERD) is more frequent in patients with diabetes mellitus (DM).The aim of the present study was to evaluate GER in asymptomatic patients with DM using 24-h pH impedance. Materials and Methods 19 healthy controls and 35 patients with DM without typical GERD symptoms were enrolled in the study. A 24-h pH-impedance study, esophageal manometry and gastroscopy were performed on all patients with DM. In the control group, an impedance study was performed o...
6 CitationsSource
Background: Gastroesophageal reflux disease (GERD) is one of the most common problems encountered in clinical practice today. The pathophysiology of GERD is complex, involving diverse factors. Aim of the work: was to assess the role of visceral fat and IL-6, adiponectin and leptin levels on reflux esophagitis in obese patients. Patients and Methods: This prospective observational case-control study included a total of 90 participants; 60 patients with reflux esophagitis and 30 age and sex-matche...
#1Roberto Monreal-Robles (Universidad Autónoma de Nuevo León)H-Index: 6
#2José María Remes-Troche (Universidad Veracruzana)H-Index: 26
Chronic hyperglycemia is a well-known cause of gastrointestinal motility disorders extending from the esophagus to the anorectum. Even though little attention has been paid to esophageal disorders in the context of DM, its prevalence is higher compared to gastroparesis. Heartburn, as a typical symptom of gastroesophageal reflux disease (GERD), is the most prevalent symptom and has been found in 25 to 41% of patients with DM. Furthermore, DM has recently been established as possible independent f...
2 CitationsSource
#1Emmanuel Marin Valdez-Solis (Mexican Social Security Institute)H-Index: 1
#2Claudia Ramírez-Rentería (Mexican Social Security Institute)H-Index: 7
Last. Víctor Rodríguez-Pérez (UNAM: National Autonomous University of Mexico)H-Index: 1
view all 6 authors...
Introduccion: Las patologias gastroesofagicas son comunes y multifactoriales en pacientes con diabetes tipo 1 (DM1). La evaluacion por medio de panendoscopia y pHmetria es costosa y dificil de realizar en todos los centros de atencion, por lo que se requieren algoritmos rentables para su diagnostico. Existen cuestionarios sencillos y autoaplicables que pueden ser utiles para el diagnostico de enfermedad por reflujo gastroesofagico en los pacientes con DM1. Objetivo: Evaluar la utilidad de los cu...
#1Mohammad Mohammadi (IUMS: Iran University of Medical Sciences)H-Index: 3
#2Nahid Ramezani Jolfaie (IUMS: Isfahan University of Medical Sciences)H-Index: 4
Last. Mitra ZarratiH-Index: 10
view all 4 authors...
CONTEXT: The incidences of both gastroesophageal reflux disease (GERD) and metabolic syndrome (MetS) have increased in recent years, and it has been suggested that there is a probable association between the two. The aim of this review is to clarify whether or not MetS is a risk factor for the incidence of GERD. EVIDENCE AQUISITION: We searched the PubMed, ProQuest, Ovid, Science Direct, and Google Scholar databases up to February 2015 regarding the relationship between GERD and MetS as found in...
5 CitationsSource
#1Jun Ouk Ha (St Mary's Hospital)H-Index: 1
#2Tae Hee Lee (Konyang University)H-Index: 16
Last. Young Woo Kang (Konyang University)H-Index: 13
view all 11 authors...
Gastrointestinal symptoms are common in patients with type 2 diabetes mellitus (T2DM). The prevalence of gastroesophageal reflux disease (GERD) in Korea appears to be increasing. Some studies have shown that T2DM is a risk factor for symptomatic GERD. However, this possibility is still debated, and the pathogenesis of GERD in T2DM is not yet fully understood. The aim of this study was to analyze the prevalence and risk factors (including autonomic neuropathy) of GERD in patients with T2DM.This c...
8 CitationsSource
#1Ping-Huei Tseng (NTU: National Taiwan University)H-Index: 17
#2Wei-Shiung Yang (NTU: National Taiwan University)H-Index: 53
Last. Ming-Shiang Wu (NTU: National Taiwan University)H-Index: 81
view all 7 authors...
Objective The pathogenesis of gastroesophageal reflux disease (GERD) is complex and poorly understood. We aim to investigate the association of various circulating peptide hormones with heterogenous manifestations of GERD. Methods One hundred and four patients that had experienced typical GERD symptoms (heartburn and/or acid regurgitation) for at least 3 episodes per week in the past 3 months were enrolled. All patients received a baseline assessment of symptom severity and frequency with the Re...
10 CitationsSource
#1Paawan Punjabi (RU: Rutgers University)H-Index: 1
#2Angela Hira (RU: Rutgers University)H-Index: 1
Last. Sita Chokhavatia (RU: Rutgers University)H-Index: 4
view all 5 authors...
This article reviews the known pathophysiological mechanisms of comorbid gastroesophageal reflux disease (GERD) in the diabetic patient, discusses therapeutic options in care, and provides an approach to its evaluation and management. We searched for review articles published in the past 10 years through a PubMed search using the filters diabetes mellitus, GERD, pathophysiology, and management. The search only yielded a handful of articles, so we independently included relevant studies from thes...
9 CitationsSource