MDM2 Polymorphism, Survival, and Histology in Early-Stage Non–Small-Cell Lung Cancer
Abstract
MDM2 is a negative regulator of p53. The MDM2 309T/G polymorphism has been associated with differential MDM2 expression levels and inhibition of the p53 pathway. We hypothesized that the MDM2 G/G genotype may be associated with worse survival outcomes in lung cancer, especially in squamous cell cancers where p53 abnormalities are more common.We evaluated the relationship between MDM2 polymorphism status and overall survival (OS) among patients...
Paper Details
Title
MDM2 Polymorphism, Survival, and Histology in Early-Stage Non–Small-Cell Lung Cancer
Published Date
Jun 1, 2007
Journal
Volume
25
Issue
16
Pages
2243 - 2247
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