Neurotensin and CRH Interactions Augment Human Mast Cell Activation
Abstract
Stress affects immunity, but the mechanism is not known. Neurotensin (NT) and corticotropin-releasing hormone (CRH) are secreted under stress in various tissues, and have immunomodulatory actions. We had previously shown that NT augments the ability of CRH to increase mast cell-dependent skin vascular permeability in rodents. Here we show that NT triggered human mast cell degranulation and significantly augmented CRH-induced vascular endothelial...
Paper Details
Title
Neurotensin and CRH Interactions Augment Human Mast Cell Activation
Published Date
Nov 14, 2012
Journal
Volume
7
Issue
11
Pages
e48934 - e48934
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